NR AMSK
AU Wood,P.L.; Etienne,P.; Lal,S.; Nair,N.P.; Finlayson,M.H.; Gauthier,S.; Palo,J.; Haltia,M.; Paetau,A.; Bird,E.D.
TI A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease
QU Journal of the Neurological Sciences 1983 Dec; 62(1-3): 211-7
PT journal article
AB Assessment of neurochemical markers in the frontal cortex indicates that choline acetyltransferase is significantly decreased in Alzheimer's and Gerstmann-Sträussler dementias but not in Pick's dementia. It therefore appears that the cholinergic innervation of the cortex from the basal forebrain is intact in Pick's disease. Cortical somatostatin was decreased only in Alzheimer's disease (AD), indicating that loss of somatostatin is not a constant feature in different forms of dementia. Muscarinic binding sites were unaltered in Pick's disease and Gerstmann-Sträussler syndrome but were decreased in a subpopulation of AD patients. These data suggest that in some cases of AD a significant loss of cholinoceptive neurones in the cortex is evident.
MH Adult; Aged; Alzheimer Disease/*metabolism/pathology; Cerebral Cortex/*metabolism/pathology; Choline O-Acetyltransferase/*metabolism; Dementia/*metabolism/pathology; Female; Human; Male; Middle Age; Oxotremorine/metabolism; Quinuclidinyl Benzilate/metabolism; Receptors, Muscarinic/*metabolism; Somatostatin/*metabolism; Support, Non-U.S. Gov't
SP englisch
PO Niederlande