NR AMTH
AU Wu,C.; Singh,S.K.; Dias,P.; Kumar,S.; Mann,D.M.A.
TI Activated astrocytes display increased 5-HT2a receptor expression in pathological states
QU Experimental Neurology 1999 Aug; 158(2): 529-33
PT journal article
AB In human brain tissues from patients dying with cerebral infarction, hypertensive encephalopathy, Alzheimer's disease, Huntington's disease, frontotemporal dementia, and Creutzfeldt-Jakob disease there is an activation of astrocytes. Such activated astrocytes display GFAP and strong 5-HT(2A), but not 5-HT(2B) or 5-HT(2C), receptor immunoreactivity; this 5-HT(2A) reaction has not been observed in normal, nonactivated astrocytes. It is suggested that an up-regulation of 5-HT(2A) receptors may be part of an early response reaction in astrocytes, possibly designed to maintain homeostasis or to induce secondary message pathways involving trophic factors or glycogenolysis.
MH Aged; Alzheimer Disease/metabolism/pathology; Astrocytes/*metabolism/pathology; Brain/*metabolism/*pathology; Brain Diseases/metabolism/*pathology; Caudate Nucleus/metabolism/pathology; Cerebrovascular Disorders/metabolism/pathology; Creutzfeldt-Jakob Syndrome/metabolism/pathology; Frontal Lobe/metabolism/pathology; Glial Fibrillary Acidic Protein/analysis; Human; Middle Age; Receptors, Serotonin/analysis/*metabolism; Reference Values; Support, Non-U.S. Gov't; Up-Regulation
AD Department of Pathological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
SP englisch
PO USA