NR ANEM
AU Galanaud,D.; Dormont,D.; Grabli,D.; Charles,P.; Hauw,J.J.; Lubetzki,C.; Brandel,J.P.; Marsault,C.; Cozzone,P.J.
TI MR spectroscopic pulvinar sign in a case of variant Creutzfeldt-Jakob disease
QU Journal of Neuroradiology. Journal de Neuroradiologie 2002 Dec; 29(4): 285-7
IA http://www.masson.fr/masson/portal/bookmark?Global=1&Page=18&MenuIdSelected=106&MenuItemSelected=0&MenuSupportSelected=12&CodeRevue4=JN&CodeProduct4=564&Path=REVUE/JN/2002/29/4/ARTICLE1110852937.xml&Locations=&Pos=11
PT journal article
AB We report MR spectroscopic findings in a patient hospitalized with biopsy-proven variant Creutzfeldt-Jakob (vCJD) disease. N-acetyl aspartate was markedly decreased in the postero-medial part of the thalami (pulvinar) but was not diminished in the parieto-occipital white matter and cortical grey matter. These observations, which are in accordance with the pathological findings in this disease, suggest that MR spectroscopy, a highly sensitive method for the detection of subtle brain metabolic dysfunction, could be of interest for the diagnosis, prognosis and therapeutic follow-up of vCJD.
AD D. Galanaud, D. Dormont, C. Marsault, Department of Neuroradiology, Hôpital La Pitié Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris Cedex 13, France; D. Grabli, P. Charles, C. Lubetzki, J. P. Brandel, Department of Neurology, Hôpital La Pitié Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris Cedex 13, France; J. J. Hauw, Department of Neuropathology, Hôpital La Pitié Salpêtrière, 47, boulevard de l'Hôpital, 75651 Paris Cedex 13, France; P. J. Cozzone, Centre de Résonance Magnétique Biologique et Médicale CNRS UMR 6612, Faculté de Médecine, 27, boulevard Jean-Moulin, 13005 Marseille, France
SP englisch
PO Frankreich