NR ANFT
AU Rivera-Milla,E.; Stuermer,C.A.O.; Malaga-Trillo,E.
TI An evolutionary basis for scrapie disease: identification of a fish prion mRNA.
QU Trends in Genetics 2003 Feb; 19(2): 72-5
PT journal article
AB Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.
AD Department of Biology, University of Konstanz, 78457, Konstanz, Germany
SP englisch
PO England