NR ANIE
AU Gavier-Widen,D.; Wells,G.A.H.; Simmons,M.M.; Wilesmith,J.W.; Ryan,J.
TI Histological observations on the brains of symptomless 7-year-old cattle
QU Journal of Comparative Pathology 2001 Jan; 124(1): 52-9
PT journal article
AB The histological changes in the brains of 506 clinically normal 7-year-old cattle, which were part of a cohort study on maternal transmission of bovine spongiform encephalopathy, are described. Vacuolation of the white matter, of unknown aetiology, located particularly in the substantia nigra, was a frequent finding. Vacuolated neurons were commonly observed in the red nucleus (64.3% of the animals) and in the habenular nucleus (50.1%). Spheroids were found in 10.8% of the brains, most frequently in the vestibular nuclei. Cellular inflammatory infiltrates in association with blood vessels occurred in 30% of the animals at various locations in the brain; their aetiology remains uncertain, but they may have reflected subclinical or latent infections. Mineralization of the wall of blood vessels, with proliferation of the intima, was observed frequently in vessels of the internal capsule and was probably associated with ageing. The description of histological findings in the brain of symptomless adult cattle in the present study provides a useful background for diagnostic bovine neuropathology.
MH Animal; Blood Vessels/pathology; Brain/*pathology; Calcinosis; Cattle; Cattle Diseases/*diagnosis/epidemiology; Cell Division; Cohort Studies; Female; Great Britain/epidemiology; Habenula/pathology; Male; Neurons/parasitology; Red Nucleus/pathology; Substantia Nigra/pathology; Support, Non-U.S. Gov't; Tunica Intima/pathology; Vacuoles/pathology
AD Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK
SP englisch
PO England
OR Prion-Krankheiten G