NR ANLZ
AU Mabbott,N.A.; Bruce,M.E.
TI Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies
QU Seminars in Immunology 2002 Aug; 14(4): 285-93
PT journal article; review; review, tutorial
AB Transmissible spongiform encephalopathies (TSEs) are often acquired peripherally, for example by ingestion or iatrogenic exposure. After entry, TSE agents, as identified by disease-specific protein accumulation, usually accumulate on follicular dendritic cells (FDCs) in lymphoid tissues long before infection spreads to the brain. Neuroinvasion of TSE agents is significantly impaired in the absence of mature FDCs. Treatments that interfere with the integrity or function of FDCs extend survival time by blocking replication in lymphoid tissues and spread to the brain. The identification of FDCs as critical for TSE pathogenesis provides a cellular target to which therapies can be specifically directed.
ZR 74
MH Animal; Dendritic Cells, Follicular/*immunology; Human; Prion Diseases/*immunology/pathology/therapy/transmission; Prions/immunology
AD Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, Edinburgh, EH9 3JF, Scotland, UK. neil.mabbott@bbsrc.ac.uk
SP englisch
PO USA