NR ANQW
AU Hooper,N.M.
TI Could inhibition of the proteasome cause mad cow disease?
QU Trends in Biotechnology 2003 Apr; 21(4): 144-5
PT journal article
AB The proteasome is the cellular machinery responsible for the degradation of normal and misfolded proteins. Inhibitors of the proteasome are being evaluated as therapeutic agents and recent work suggests that such inhibition might promote the neurotoxic properties of the prion protein (the causative agent of mad cow disease) and its conformational conversion to the infectious form, thus raising the question as to whether proteasome inhibitors might facilitate the development of prion diseases.
AD School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK
SP englisch
PO England
OR Prion-Krankheiten H