NR ANRI
AU Kogan,E.A.; Zelenkov,P.V.; Uspenskaia,O.V.; Epifanov,I.a.V.
TI [Prion diseases: current views]
OT Prionnye bolezni: sovremennyi vzgliad na problemu.
QU Arkhiv Patologii 2002 Nov-Dec; 64(6): 3-9
PT editorial; review; review, tutorial
AB This is a review of the problem. The above diseases represent a peculiar type of fatal neurodegenerative diseases of man and animals provoker of which is prion - a low molecular anucleinic protein resistant to inactivation. Human prior diseases include fatal familial sleeplessness, Creutzfeldt-Jakob disease, kuru, Gerstmann-Sträussler-Scheinker's syndrome, etc. Prion proteins possess a characteristic capacity to change a tertiary conformation resulting in the formation of a pathological form of protein having infectious properties. Pathogenesis, morphological and clinical manifestations as well as principles of diagnosis and treatment of these diseases are discussed.
ZR 24
MH Animal; Brain/*pathology; English Abstract; Human; Prion Diseases/classification/etiology/*pathology; Prions/genetics/*pathogenicity
SP russisch
PO Russland