NR ANSD
AU Oidtmann,B.; Simon,D.; Holtkamp,N.; Hoffmann,R.W.; Baier,M.
TI Identification of cDNAs from Japanese pufferfish (Fugu rubripes) and Atlantic salmon (Salmo salar) coding for homologues to tetrapod prion proteins
QU FEBS Letters 2003 Mar 13; 538(1-3): 96-100
PT journal article
AB We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon (Salmo salar) and Japanese pufferfish (Fugu rubripes), which were termed 'similar to PrPs' (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod PrPs. In addition, two stPrPs were shown to be highly expressed in brain tissue. None of the so far identified PrP-homologues of fish resembles doppel. Hence, the duplication of the PrP gene, which generated doppel, may have occurred not in fish but later in the tetrapod lineage. The identification of fish PrPs provides a basis to address concerns about a possible susceptibility of fish to prion infections.
AD Institute of Zoology, Fish Biology and Fish Diseases, Veterinary Faculty, University of Munich, Kaulbachstr. 37, 80539, Munich, Germany
SP englisch
PO Niederlande