NR ANXA
AU Bonora,S.; Zanusso,G.; Raiteri,R.; Monaco,S.; Rossati,A.; Ferrari,S.; Boffito,M.; Audagnotto,S.; Sinicco,A.; Rizzuto,N.; Concia,E.; Di Perri,G.
TI Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis
QU Clinical Infectious Diseases 2003 Jun 1; 36(11): 1492-5
PT journal article
AB The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.
MH Biological Markers/cerebrospinal fluid; Cerebrospinal Fluid Proteins/*cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid; Human; Meningitis, Bacterial/*cerebrospinal fluid/mortality; Prognosis; Prospective Studies; Tyrosine 3-Monooxygenase/*cerebrospinal fluid
AD Department of Infectious Diseases, University of Turin, Turin, Italy.
SP englisch
PO USA