NR ANYT
AU Mochizuki,Y.; Mizutani,T.; Tajiri,N.; Oinuma,T.; Nemoto,N.; Kakimi,S.; Kitamoto,T.
TI Creutzfeldt-Jakob disease with florid plaques after cadaveric dura mater graft
QU Neuropathology 2003 Jun; 23(2): 136-40
PT journal article
AB A patient with dura-associated Creutzfeldt-Jakob disease (D-CJD) which occurred about 15 years after a dura mater graft is reported in the present study. The prion protein gene analysis disclosed no mutation. The D-CJD was atypical in: (i), the long interval between the onset of ataxia and the occurrence of dementia; (ii), the presence of transient myoclonus; and (iii), the presence of florid plaques in the brain. The electron-microscopic findings showed bundles of amyloid filaments which radiated from the center of the plaques without degenerating neurites. This case of D-CJD may belong to a new subtype of D-CJD.
MH Ataxia/etiology; Blotting, Western; Brain/pathology/ultrastructure; Brain Tissue Transplantation/adverse effects; Cadaver; Case Report; Creutzfeldt-Jakob; Syndrome/*classification/*etiology/pathology/physiopathology; Dementia/etiology; Dura Mater/pathology/*transplantation/ultrastructure; Fatal Outcome; Female; Human; Middle Age; Prions/metabolism; Senile Plaques/pathology; Support, Non-U.S. Gov't; Time Factors
AD Division of Neurology, Department of Medicine, Nihon University School of Medicine,Tokyo, Japan. mochi@ica.nihon-u.ne.jp
SP englisch
PO Australien