NR AODB
AU Mendez,O.E.; Shang,J.; Jungreis,C.A.; Kaufer,D.I.
TI Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
QU Journal of Neuroimaging 2003 Apr; 13(2): 147-51
PT journal article; review; review of reported cases
AB Two middle-aged patients presented with rapidly progressive dementia and ataxia, nonspecific electroencephalography findings, and negative cerebrospinal fluid (CSF) protein 14-3-3. Both patients underwent brain magnetic resonance imaging (MRI) scans that demonstrated abnormalities on diffusion-weighted imaging (DWI) sequences, and both were later confirmed to have Creutzfeldt-Jakob disease. (CJD) by tissue examination. Because a recent position paper from the American Academy of Neurology characterized CSF protein 14-3-3 as a gold standard for clinically diagnosing CJD, the authors reviewed studies of CJD in which DWI-MRI imaging and CSF protein 14-3-3 studies were both performed. Among 19 reported cases of CJD with DWI-MRI lesions, CSF protein 14-3-3 was negative in 6 cases and positive in 2 others. The authors' findings suggest that multifocal cortical and subcortical hyperintensities confined to gray matter regions in DWI-MRI may be a more useful noninvasive diagnostic marker for CJD than CSF protein 14-3-3. These observations provide a compelling rationale for a prospective comparative study.
ZR 23
MH Aged; Case Report; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/*diagnosis; Fatal Outcome; Female; Human; Magnetic Resonance Imaging/*methods; Male; Support, U.S. Gov't, P.H.S.; Tyrosine 3-Monooxygenase/cerebrospinal fluid
AD Department of Neurology, University of Pittsburgh School of Medicine.
SP englisch
PO USA