NR AOFF
AU Bussard,A.E.
TI [Is the prion abnormality going to involve immunology?]
OT L'anomalie des prions va-t-elle ebranler l'immunologie?
QU Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 2003; 158(1-2): 121-30; discussion 130-1
PT journal article
AB The behaviour of prion type proteins, be they in mammals (Pr P) or in yeast (URE 3) suggests a non Mendelian heredity based on conformational changes in these proteins. This seems to be an anomaly in regard to molecular Biology (M.B.) which rules information transfer exclusively from DNA to protein with the use of a numeric code. This anomaly may affect M.B. in the future, but also may influence our views in Immunology. For the time being, clonal selection is the only accepted theory to explain the generation of diversity in antibodies; is it full proof?
MH English Abstract; Human; Molecular Biology; Prion Diseases/genetics/*immunology; Prions/genetics/*immunology
SP französisch
PO Belgien