NR AOGB
AU Hegde,R.S.; Rane,N.S.
TI Prion protein trafficking and the development of neurodegeneration
QU Trends in Neurosciences 2003 Jul; 26(7): 337-9
KZ Science. 2002 Nov 29;298(5599):1781-5. PMID: 12386337 Science. 2002 Nov 29;298(5599):1785-8. PMID: 12386336
PT comment; journal article; review; review, tutorial
AB The prion protein (PrP) is involved in causing a group of diverse transmissible, heritable and sporadically occurring neurodegenerative diseases. Although the identity, nature and replication of the transmissible agent have been intensely studied for decades, the cellular events underlying neuronal dysfunction and death have received comparatively little attention. Recent studies examining the occurrence and consequences of inappropriate cytoplasmic expression of the normally cell-surface PrP underscore an emerging role for PrP trafficking in prion disease pathogenesis.
ZR 17
MH Animal; Cytoplasm/*metabolism; Nerve Degeneration/*metabolism; Prions/metabolism/*toxicity; Signal Transduction
AD Cell Biology and Metabolism Branch, NICHD/National Institutes of Health, Bethesda, MD 20892, USA. hegder@mail.nih.gov
SP englisch
PO England