NR AOGP
AU Kurup,R.K.; Kurup,P.A.
TI Hypothalamic-mediated model for Creutzfeldt-Jakob disease: relation to hemispheric chemical dominance.
QU International Journal of Neuroscience 2003 Jul; 113(7): 971-87
PT journal article
AB The isoprenoid pathway including endogenous digoxin was assessed in Creutzfeldt-Jakob Disease (CJD). This was also studied for comparison in patients with right hemispheric and left hemispheric dominance. The isoprenoid pathway was upregulated with increased digoxin synthesis in patients with CJD and in those with right hemispheric chemical dominance. In this group of patients (i) the tryptophan catabolites were increased and the tyrosine catabolites reduced, (ii) the dolichol and glycoconjugate levels were elevated, (iii) lysosomal stability was reduced, (iv) ubiquinone levels were low and free radical levels increased, and (v) the membrane cholesterol:phospholipid ratios were increased and membrane glyco conjugates reduced. On the other hand, in patients with left hemispheric chemical dominance, the reverse patterns were obtained. The role of the isoprenoid pathway in the pathogenesis of CJD and its relation to hemispheric chemical dominance is discussed.
MH Brain Chemistry/physiology; Comparative Study; Creutzfeldt-Jakob Syndrome/*physiopathology; Digoxin/*blood; Dolichol/blood; Dominance, Cerebral/*physiology; Enzyme Inhibitors/blood; Erythrocyte Membrane/*metabolism; Free Radicals/blood; Glycoproteins/blood; Glycosaminoglycans/blood; Human; Hydroxymethylglutaryl CoA Reductases/blood; Hypothalamus/metabolism; Lipid Peroxidation/physiology; Lysosomes/metabolism; Magnesium/blood; Matched-Pair Analysis; Models, Biological; Models, Neurological; Na(+)-K(+)-Exchanging ATPase/*metabolism; Neurotransmitters/metabolism; Polyisoprenyl Phosphates/metabolism; Tryptophan/metabolism; Tyrosine/metabolism; Ubiquinone/blood
AD Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
SP englisch
PO USA