NR AOZM
AU Stoeck,K.; Bodemer,M.; Poser,S.; Zerr,I.
TI Cytokines in the cerebrospinal fluid in Creutzfeldt-Jakob-disease
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Poster session - DG-23
PT Konferenz-Poster
AB
Creutzfeldt-Jakob-disease (CJD) is a neurodegenerative disease within the central nervous system (CNS). The idea for this investigation was the analysis of the potential role of cytokines following neurodegeneration.
Concentrations of the interleukins (IL) IL-1 beta, IL-6, IL-8, IL-12, Tumor Necrosis Factor (TNF)-alpha and Transforming Growth Factor (TGF)-beta 2 were detected in cerebrospinal fluid (CSF) and serum from patients with CJD and controls using commercially available ELISA-testkits.
Tests were conducted in patients of the following diagnosis: CJD, various dementia, inflammatory CNS-diseases and healthy controls.
The investigation of IL-8 in CSF showed a significant elevation in CJD compared to healthy controls and to other dementia. There was no significant difference between CJD and inflammatory CNS-diseases.
TGF-beta 2 was significantly decreased in CSF in CJD compared to all investigated groups.
IL-1 beta, IL-6, IL-12 and TNF-alpha could not be detected in CSF in all investigated groups.
IL-8 levels were elevated in the CSF of CJD patients. Of importance, the elevation was significant to other dementia and to controls.
In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups, especially to other dementia .
These findings may be interesting in view of pathophysiological processes involved in CJD following neurodegeneration. A potential utility of IL-8 and TGF-beta 2 in diagnosis of CJD has to be investigated further.
AD K. Stoeck, M. Bodemer, S. Poser, I. Zerr, Department of Neurology, Georg-August-University Göttingen, Germany
SP englisch
PO Deutschland