NR APAX
AU Zorrilla,S.; Elvira,G.; Gonzalez-Iglesias,R.; Pajares,M.A.; Velez,M.; Rodriguez-Navarro,J.A.; Gasset,M.
TI Generation of the prion protein nuclei for its polymerization
QU International Conference - Prion diseases: from basic research to intervention concepts - TSE-Forum, 08.10.-10.10.2003, Gasteig, München - Poster session - BR-20
PT Konferenz-Poster
AB Most prion diseases result from the accumulation of alternative conformers of the cellular prion protein with enhanced aggregation tendency. The aggregation event results in the formation of amorphous protein deposits that can acquire a fibrilar aspect if partial proteolysis occurs. Using an acidic perturbing medium, we have stabilized a more compact form of full length PrP. This conformer remains as a monomer in our diluted solution conditions, but when a significant proportion of the solution volume is occupied by an inert macromolecule, the protein can undergo nucleated-polymerization
AD Silvia Zorrilla, Gema Elvira, Reinerio Gonzalez-Iglesias, Jose A. Rodriguez-Navarro, Maria Gasset, IQFR, CSIC, Spain; Silvia Zorrilla, Maria A. Pajares, IIB, CSIC-UAM, Spain; Marisela Velez, INC, UAM, Spain
SP englisch
PO Deutschland