NR APKN
AU Oishi,T.; Hagiwara,K.; Kinumi,T.; Yamakawa,Y.; Nishijima,M.; Nakamura,K.; Arimoto,H.
TI Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145)
QU Organic and Biomolecular Chemistry 2003 Aug 7; 1(15): 2626-9
PT journal article
AB The effects of Soto's 'beta-sheet breaker peptide' and its polymer on PrPsc formation in ScN2a cells were investigated. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the 'beta-sheet breaker peptide' is not specific and may not play a major role in the inhibition of PrPsc formation.
MH Amino Acid Sequence; Animals; Biopolymers/chemistry/*metabolism; Mice; Molecular Sequence Data; Neuroblastoma/*metabolism/pathology; Peptide Fragments/chemistry/*metabolism; Peptides/chemistry/*metabolism; PrPsc Proteins/*pathogenicity; Prions/chemistry/*metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Support, Non-U.S. Gov't; Surface Plasmon Resonance; Tumor Cells, Cultured
AD Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
SP englisch
PO England