NR APLM
AU Saupe,S.J.
TI New anti-prion drugs make yeast blush
QU Trends in Biotechnology 2003 Dec; 21(12): 516-9
PT journal article; review; review literature
AB Prions are misfolded proteins capable of propagating their altered conformational state. They have been identified as the causative agents of a class of neurodegenerative diseases termed spongiform encephalopathies. No treatment for prion diseases is currently available. In a recent paper, Bach et al. describe a yeast-based approach for the development of anti-prion drugs. This approach could prove convenient for the identification and improvement of anti-prion pharmacologicals. From a fundamental point of view this study underscores the mechanistic similarities between mammalian and yeast prions.
ZR 24
MH Biotechnology/*trends; *Drug Design; Prion Diseases/drug therapy; Prions/*chemistry; Technology, Pharmaceutical/*trends; Yeasts/*chemistry/drug effects
AD Laboratoire de Genetique Moleculaire des Champignons, Institut de Biochimie et de Genetique Cellulaire, UMR 5095, CNRS Universite de Bordeaux II, Bordeaux, France.
SP englisch
PO England