NR APML
AU Tabrizi,S.J.; Elliott,C.L.; Weissmann,C.
TI Ethical issues in human prion diseases
QU British Medical Bulletin 2003; 66: 305-16
PT journal article; review; review, tutorial
AB Prion diseases or transmissible spongiform encephalopathies are a group of closely related transmissible neurodegenerative conditions of humans and animals, all of which are incurable. In recent years, they have captured public attention with the emergence of the bovine spongiform encephalopathy (BSE) epidemic in Europe, and more recently with the appearance of variant CJD (vCJD) in humans, a novel form of Creutzfeldt-Jakob disease (CJD) that is linked to dietary exposure to BSE. In this chapter, we outline ethical questions posed by research, diagnostic procedures and therapy in the field of prion diseases.
ZR 43
MH Adolescent; Adult; Aged; Amyloid/genetics; Anonymous Testing/ethics; Appendix/chemistry; Child; Diet; *Ethics, Clinical; Female; Genetic Diseases, Inborn; Genetic Screening/ethics; Great Britain; Homozygote; Human; Human Experimentation/ethics; Legislation, Medical; Male; Methionine/genetics; Middle Aged; Polymorphism (Genetics); PrPsc Proteins/analysis; Pregnancy; Preimplantation Diagnosis/ethics; *Prion Diseases/genetics/prevention & control/therapy; Protein Precursors/genetics; Randomized Controlled Trials/ethics; Risk Assessment; Support, Non-U.S. Gov't; Tonsil/chemistry
AD Department of Neurodegenerative Disease/MRC Prion Unit, Institute of Neurology, London, UK
SP englisch
PO England