NR APNL
AU Zuev,V.A.; Roikhel',V.M.; Ignatova,N.G.
TI [Gliosis as a trigger of pathomorphological changes in prion diseases]
OT Glioz kak puskovoi mekhanizm patomorfologicheskikh izmenenii pri prionnykh bolezniakh
QU Voprosy Virusologii 2003 Jul-Aug; 48(4): 35-7
PT journal article
AB Experiments with three cell lines revealed that the scraplecontaining cerebral extract, obtained from preliminarily infected 6-month mice, sharply induced the cellular proliferation, which was registered yet in 3 days after incubation. However, the cerebral extract of healthy 6-month mice did not virtually influence the velocity of cells' reproduction in all three cultures. The authors suggest, with respect to published data and to their independently found research results, that the gliosis of primary importance in shaping up the pathomorphological alterations in the cerebral tissue in prion diseases of man and animal.
MH Animals; Brain/pathology; Cell Division/drug effects; Cell Line/drug effects; English Abstract; Gliosis/*pathology; Mice; Neuroglia/pathology; Prions/pharmacology; Scrapie/*pathology; Time Factors; Tissue Extracts/pharmacology
SP russisch
PO Russland