NR APTL
AU Dormont,D.
TI Safeguards for the prevention of transmission of prions during grafting
QU Medecine et Maladies Infectieuses 1996; 26(NBIS): 281-91
PT Article
AB Creutzfeldt-Jakob disease (CJD) and the agents reponsible for its transmission remain an enigma. The recent contamination of children treated with pituitary-derived growth hormone have had certain consequences : it has focused the attention of physicians on the necessity for strict control of biological products which are used in human therapy and for virological evaluation of manufacturing processes; it has proved that clinical signs of CJD sometimes depend on the origin of the infection and on age of onset; it has clearly shown the need to follow up all individuals treated regularly with this type of human product. Risk associated with grafting can be avoided by : use of synthetic or biotechnological products; rigorous donor selection : it is advisable to avoid grafting organs from donors who have a family history of CJD or degenerative encephalopathies or who have been treated with hypophyseal hormone extracts; the use, where possible, of organs with only slight infectious likelihood. However, the appearance of bovine spongiform encephalopathy in the UK has proved that in certain conditions transmissible degenerative diseases (TND) may cause an epidemic and they have economic and animal health consequences. The overlap of the transmissible agent and host genetics in TND is astonishing and unprecedented in the field of infectious diseases. It is for this reason, and because TSE are degenerative diseases whose mechanisms could resemble Alzheimer's disease and problems related to normal aging, that prions constitute one of the most promising areas of modern biological research.
ZR 77
SP französisch