NR APVJ
AU Race,R.E.; Raymond,G.J.
TI Inactivation of transmissible spongiform encephalopathy (prion) agents by environ LpH
QU Journal of Virology 2004 Feb; 78(4): 2164-5
IA http://www.cwd.cc/Inactivation%20of%20Transmissible%20Spongiform%20Encephalopathy%20(Prion).pdf
PT journal article
AB Agents causing transmissible spongiform encephalopathy (TSE) diseases are resistant to inactivation by several conventional decontamination methods. Using an animal bioassay, we compared the TSE agent disinfectant efficacy of a commercially available product referred to alternatively as LpH-SE, LpH-AG, or LpH-st to that of a similarly named but differently formulated product, Environ LpH, which was found to be an effective TSE agent disinfectant in a previous study. Here, we found LpH-SE to be at least 10(4)-fold to 10(5)-fold less effective than Environ LpH.
MH Animals; Brain/drug effects/metabolism; Glycols/chemistry/*pharmacology; Hamsters; Mesocricetus; Prion Diseases/*metabolism/prevention & control; Prions/*drug effects/pathogenicity; Propanols/chemistry/*pharmacology
AD Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. rrace@niaid.nih.gov
SP englisch
PO USA