NR APVT
AU Schmidt,H.; Otto,M.; Niedmann,P.; Cepek,L.; Schröter,A.; Kretzschmar,H.A.; Poser,S.
TI CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias
QU Dementia and Geriatric Cognitive Disorders 2004; 17(3): 204-6
PT journal article
AB The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (n = 26) were compared with those in other dementias (n = 28). LDH isoenzymes were determined in a subset (n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias.
MH Aged; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*enzymology; Dementia/*cerebrospinal fluid/*enzymology; Diagnosis, Differential; Female; Human; Isoenzymes/cerebrospinal fluid; L-Lactate Dehydrogenase/*cerebrospinal fluid; Male; Middle Aged; Psychiatric Status Rating Scales; Support, Non-U.S. Gov't
AD Department of Neurology, University of Göttingen, Göttingen, Germany. hschmid2@gwdg.de
SP englisch
PO Schweiz