NR AQCJ
AU Brooke,F.J.; Boyd,A.; Klug,G.M.; Masters,C.L.; Collins,S.J.
TI Lyodura use and the risk of iatrogenic Creutzfeldt-Jakob disease in Australia
QU Medical Journal of Australia 2004 Feb 16; 180(4): 177-81
IA http://www.mja.com.au/public/issues/180_04_160204/bro10566_fm.pdf
PT journal article
AB Although infectiousness is a feature of Creutzfeldt-Jakob disease (CJD), only a small proportion of cases are linked to transmission through healthcare provision. As of January 2003, over 120 cases of CJD associated with use of human cadaveric dura mater had been recognised worldwide; almost all were associated with the commercial product Lyodura. Most cases (97) have occurred in Japan, giving an overall risk estimate of around 1 per 2268 patients treated with Lyodura (0.04%) in that country. In Australia, five cases of CJD have so far been linked to Lyodura, but, given the protracted tails of previous epidemics of transmissible spongiform encephalopathies, further cases are possible. Results of surveys of Lyodura use in Australia are incomplete, but information from the manufacturer suggests that 2208-2478 sheets of Lyodura may have been used here. This use translates to a relatively high incidence of Lyodura-associated CJD, with current overall rates appearing around five times higher than those reported in Japan; reasons for this difference are unclear.
MH Australia/epidemiology; *Collagen; Creutzfeldt-Jakob Syndrome/epidemiology/*transmission; Dura Mater/*transplantation; Human; *Iatrogenic Disease; Japan/epidemiology; Risk; Safety; Support, Non-U.S. Gov't
AD
Fiona J Brooke, Alison Boyd, Genevieve M Klug, Colin L Masters and Steven J Collins,
Section MDP14, Communicable Diseases Branch, Department of Health and Ageing, GPO Box 9848, Canberra, ACT 2601, Australia. Fiona.Brooke@health.gov.au
SP englisch
PO Australien