NR ARDO
AU Wünsch,G.; Herms,J.W.; Kretzschmar,H.A.
TI Role of copper and manganese in prion disease progression
QU TSE-Forum, 4. Kongress - Nationale TSE-Forschungsplattform, Düsseldorf 28.10.-29.10.2004, Poster PATH-02
PT Konferenz-Poster
AB The N-terminal part of the prion protein (PrP) contains metal ion binding sites with high specificity for copper. Other metal ions such as iron or manganese are known to be widely involved in neurodegenerative disorders and also bind to PrP but with much lower affinities. In prion diseases alterations in the levels of copper and manganese have been described both in mice infected with scrapie as well as in brains of CJD-patients. In order to get more information if alterations in the metal ion content are involved in prion disease progression, we tried to affect the whole brain copper and manganese content by dietetic means. High amounts of manganese (2000 µg/g) or copper (0,25g/l) within the food or water were not found to affect the scrapie incubation time significantly, independent of the mode of infection. Whereas a copper poor diet (1 µg/g) caused a 17,3 days earlier onset of the terminal disease compared to the control group following intraperitoneal inoculation.
AD G. Wünsch, J. Herms and H.A. Kretzschmar, Zentrum für Neuropathologie und Prionforschung (ZNP) der LMU, Feodor-Lynen-Str. 23, 81377 München
SP englisch
PO Deutschland
OR Tagungsband