NR AREY
AU Baier,M.; Schwarz,A.; Mielke,M.
TI Alkaline and phenolic cleaners/disinfectants for prion inactivation
QU TSE-Forum, 4. Kongress - Nationale TSE-Forschungsplattform, Düsseldorf 28.10.-29.10.2004, Poster INAK-01
PT Konferenz-Poster
AB A routinely usable alkaline cleaner for medical devices and a phenolic disinfectant were tested for their capacity to inactivate prions. Co-incubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the cleaner/disinfectant led to the denaturation of misfolded protein as proteinase K-resistant prion protein was no longer detectable after treatment. In addition, intracerebral inoculation of hamsters with neutralized cleaner/disinfectant-incubated samples reduced the level of infectivity of the material below the limit of detection. This report demonstrates the potency of a routinely usable alkaline cleaner and a phenolic disinfectant to reduce the infectivity of prions and to minimize the risk of iatrogenic transmissions of prion diseases by asymptomatic carriers. Our study encourages further investigations in this field.
AD Michael Baier, Anja Schwarz, Martin Mielke, Robert-Koch-Institut, Nordufer 20, 13353 Berlin
SP englisch
PO Deutschland
OR Tagungsband