NR ARHH
AU Gombojav,A.; Ishiguro,N.; Horiuchi,M.; Shinagawa,M.
TI Unique amino acid polymorphisms of PrP genes in Mongolian sheep breeds
QU Journal of Veterinary Medical Science 2004 Oct; 66(10): 1293-5
PT journal article
AB To characterize amino acid polymorphisms of sheep prion protein (PrP) gene, DNA from 740 sheep of nine breeds raised in Mongolia was isolated and analyzed. A total of 16 genotypes and seven allelic variants of the PrP gene at codons 112, 136, 154, and 171 were found. The MARQ/MARQ genotype associated with susceptibility to scrapie was found in 82.6% of the sheep while the MARR/MARR genotype associated with resistance to scrapie was found in 1.8% of the sheep. The polymorphisms of valine and serine at codon 127, and leucine and arginine at codon 189 were detected in eight Mongolian sheep breeds, suggesting that these polymorphisms are a common feature among Mongolian sheep breeds.
MH Amino Acid Sequence; Animals; Comparative Study; Genotype; Mongolia; *Polymorphism, Genetic; Prions/*genetics; Research Support, Non-U.S. Gov't; Sequence Analysis, DNA; Sheep/*genetics; Species Specificity
AD Laboratory of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
SP englisch
PO Japan