NR ARLO
AU Moum,T.; Olsaker,I.; Hopp,P.; Moldal,T.; Valheim,M.; Moum,T.; Benestad,S.L.
TI Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases
QU Journal of General Virology 2005 Jan; 86(1): 231-5
PT journal article
AB Until June 2004, thirty-eight scrapie cases with unusual features, designated Nor98, have been diagnosed in Norway. This study investigated the distribution of PrP genotypes among Nor98 cases, their flock-mates and a random sample of Norwegian slaughtered sheep. The PrP genotype distribution of Nor98 cases differed markedly from that of previous cases of classical scrapie. A leucine/phenylalanine polymorphism at codon 141 with hitherto unknown significance to scrapie was strongly associated with Nor98 cases. Twenty of 38 (52.6 %) cases were either homozygous or heterozygous for phenylalanine at codon 141. In contrast, this allele was present in only 10.5 % of the flock-mates and 4.5 % of the random sample of slaughtered sheep. Moreover, the H(154) allele was represented in 24 of 38 (63.2 %) of Nor98 cases, as opposed to 27.0 % of Nor98 flock-mates and 17.0 % of the slaughtered sheep.
MH Alleles; Animals; Codon/*genetics; Genotype; Norway/epidemiology; Odds Ratio; *Polymorphism, Genetic; Prions/*genetics; Research Support, Non-U.S. Gov't; Scrapie/epidemiology/*genetics; Sheep
AD Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Kyrkjevegen 332-334, N-4325 Sandnes, Norway. Truls.Moum@veths.no
SP englisch
PO England