NR ARMS
AU Zerr,I.; Bodemer,M.; Kaboth,U.; Kretzschmar,H.A.; Oellerich,M.; Armstrong,V.W.
TI Plasminogen activities and concentrations in patients with sporadic Creutzfeldt-Jakob disease
QU Neuroscience Letters 2004 Nov 23; 371(2-3): 163-6
PT journal article
AB Human plasminogen has been shown to interact with the abnormal disease-specific prion protein. Till now, no data are available for patients with Creutzfeldt-Jakob disease (CJD). Therefore, we compared plasminogen concentrations and plasminogen activities in patients with sporadic CJD and controls with other dementia, which were collected in the framework of the German CJD Surveillance study. Patients with CJD had significantly higher plasminogen concentrations than patients with other forms of dementia and plasminogen specific activities were lower in CJD patients. The reasons for these abnormalities are not clear at the moment. The results may reflect a disease-specific prion protein and plasminogen interaction in patients with CJD. Other possible explanations are plasminogen polymorphisms and genotypes with distinct plasminogen activity levels in CJD than in controls, which should be a subject for further studies.
MH Aged; Comparative Study; Creutzfeldt-Jakob Syndrome/*blood/psychology; Enzyme Activation; Female; Humans; Male; Middle Aged; Plasminogen/*metabolism; Research Support, Non-U.S. Gov't; Statistics, Nonparametric
AD Department of Neurology, Georg-August University, Robert-Koch-Str. 40, 37075 Göttingen, Germany. IngaZerr@aol.com
SP englisch
PO Irland