NR ARMV
AU Chernoff,Y.O.
TI Replication vehicles of protein-based inheritance
QU Trends in Biotechnology 2004 Nov; 22(11): 549-52
PT journal article
AB Prions are self-perpetuating protein isoforms that are responsible for infectious diseases in mammals and for heritable traits in fungi. Most known prion proteins form amyloids - self-seeded fiber-like aggregates. Prion propagation ('replication') could be described as a sequence of repetitive cycles of aggregate 'shearing' into smaller seeds followed by the growth of these seeds into full-size polymers. Recent work shows that the ability to form aggregates and to propagate them is controlled by distinct regions of the composite prion domains (PrDs).
MH Animals; Binding Sites; Dimerization; Evolution, Molecular; Humans; *Models, Biological; Models, Chemical; *Models, Genetic; *Models, Molecular; Molecular Conformation; Multiprotein Complexes/*genetics/*metabolism; Prion Diseases/genetics/metabolism; Prions/*chemistry/*genetics/metabolism; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Research Support, U.S. Gov't, P.H.S.; Structure-Activity Relationship
AD School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332-0363, USA. yury.chernoff@biology.gatech.edu
SP englisch
PO England