NR ARNF
AU Lasmezas,C.I.; Comoy,E.E.; Hawkins,S.A.C.; Herzog,C.; Mouthon,F.; Konold,T.; Auvre,F.; Correia,E.; Lescoutra-Etchegaray,N.; Sales,N.; Wells,G.; Brown,P.; Deslys,J.P.
TI Risk of oral infection with bovine spongiform encephalopathy agent in primates
QU Lancet 2005 Feb 26; 365(9461): 781-3
KI Lancet. 2005 Feb 26;365(9461):730-1. PMID: 15733699
PT journal article
AB The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE) - which can lead to variant Creutzfeldt-Jakob disease (vCJD) - is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man.
IN
Zwei bereits 4 Jahre alte auch Javaneraffen genannte Langschwanzmakaken (Macaca fascicularis, engl. Cynomolgus macaque) wurden mit je 5 g Hirnhomogenat einer BSE-kranken Kuh oral inokuliert. Ein Affe erkrankte nach 60 Monaten, während der andere nach 76 Monaten noch gesund war.
Lasmézas et al. berichten von einer unveröffentlichten Studie, in der von 15 oral mit je 1 mg Hirnhomogenat BSE-kranker Rinder inokulierten Rindern eines erkrankte.
MH Animals; Brain/pathology; Brain Chemistry; Cattle; Creutzfeldt-Jakob Syndrome/transmission; Eating; Encephalopathy, Bovine Spongiform/pathology/*transmission; *Food Contamination; Macaca fascicularis; PrPsc Proteins/analysis; Primate Diseases/*transmission; Research Support, Non-U.S. Gov't
AD Corinne Ida Lasmézas, Emmanuel Comoy, Christian Herzog, Franck Mouthon, Frédéric Auvré, Evelyne Correia, Nathalie Lescoutra-Etchegaray, Nicole Salès, Jean-Philippe Deslys (jpdeslys@cea.fr), Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Départment de Recherche Médicale, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France; Stephen Hawkins, Timm Konold ,Gerald Wells, Veterinary Laboratories Agency, New Haw, Addlestone, UK; Paul Brown, 7815 Exeter Road, Bethesda, MD 20814, USA
SP englisch
PO England