NR AROV
AU DeArmond,S.J.
TI Discovering the mechanisms of neurodegeneration in prion diseases
QU Neurochemical Research 2004 Nov; 29(11): 1979-98
PT journal article; review
AB The purpose of my chapter in this issue of Neuroscience Reviews dedicated to Dr. Lawrence Eng is to summarize my contributions to understanding the mechanisms of neurodegeneration in prion diseases. I explain that I was able to advance the field of prion disease neuropathology largely because of the foundation of neurochemistry and immunohistochemistry that I learned while working 5 years in Dr. Eng's laboratory. In my review, I relate how my Neuropathology Research Laboratory began as a collaboration with Dr. Stanley Prusiner 20 years ago that led from immunohistochemical staining of amyloid plaques in rodent and human brains using prion protein-specific antibodies to molecular evidence that the abnormal prion protein, PrPsc, is the cause of the clinically relevant neuropathological changes in animal and human prion diseases.
ZR 86
MH Animals; Cell Membrane/pathology; Disease Progression; Humans; Immunohistochemistry; Neurodegenerative Diseases/etiology/metabolism/*pathology; Prion Diseases/metabolism/*pathology; Prions/genetics/metabolism; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
AD Department of Pathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, 94143-0511, USA. sdearmo@itsa.ucsf.edu
SP englisch
PO USA