NR ARUX
AU Casalone,C.; Corona,C.; Crescio,M.I.; Martucci,F.; Mazza,M.; Ru,G.; Bozzetta,E.; Acutis,P.L.; Caramelli,M.
TI Pathological prion protein in the tongues of sheep infected with naturally occurring scrapie
QU Journal of Virology 2005 May; 79(9): 5847-9
PT journal article
AB Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent European Food Safety Authority opinion recommended research into PrPsc accumulation in the tongues of ruminants. We report on the detection of PrPsc in the tongues of seven scrapie-infected sheep by immunohistochemistry and Western blotting.
MH Animals; Blotting, Western; Immunohistochemistry; PrPsc Proteins/isolation & purification/*metabolism; Research Support, Non-U.S. Gov't; Scrapie/*metabolism; Sheep/*metabolism; Tongue/anatomy & histology/*metabolism
AD Cristina Casalone, Cristiano Corona, Maria Ines Crescio, Francesca Martucci, Maria Mazza, Giuseppe Ru, Elena Bozzetta, Pier Luigi Acutis, Maria Caramelli, CEA-IZS Piemonte, Liguria e Valle d'Aosta, Via Bologna, 148 Turin 10154, Italy
SP englisch
PO USA