NR ARVB
AU Magri,G.; Clerici,M.; Dall'Ara,P.; Biasin,M.; Caramelli,M.; Casalone,C.; Giannino,M.L.; Longhi,R.; Piacentini,L.; Della Bella,S.; Gazzuola,P.; Martino,P.A.; Pollera,C.; Puricelli,M.; Servida,F.; Crescio,M.I.; Boasso,A.; Ponti,W.; Poli,G.
TI Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters
QU Vaccine 2005 Apr 22; 23(22): 2862-8
PT journal article
AB Effective therapy for prion diseases is currently unavailable. Recently, vaccination was shown to be effective in mouse models of a particular neurodegenerative conditions: Alzheimer's disease (AD). Here, we report that vaccination with synthetic oligopeptides homologous to the hamster (Mesocricetus auratus) prion protein augments survival time in animals infected intraperitoneally with 263K scrapie agent. For each hamster included in the study, prion-specific serum antibodies as well as deposition of pathological prion protein (PrPres), glial fibrillary acidic protein (GFAP), and mRNA expression for cytokines (TNF alpha, IL-1ß, IL-10) in brain tissues were evaluated. In immunized animals, increased survival after challenge was associated with a reduction of cerebral lesion, PrP deposition and GFAP expression; in these animals, anti-prion protein peptide antibody levels were increased, and the expression of pro-inflammatory cytokines (TNF alpha and IL-1ß) was reduced. Vaccination could be an effective therapeutic approach to postpone disease onset.
MH Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Hamsters; Immunohistochemistry; Interleukin-1/genetics/metabolism; Interleukin-10/metabolism; Mesocricetus; Molecular Sequence Data; Peptides/*administration & dosage/chemistry; Prions/*administration & dosage/chemistry; RNA, Messenger/metabolism; Research Support, Non-U.S. Gov't; Scrapie/*pathology/prevention & control; Tumor Necrosis Factor-alpha/genetics
AD Giuliana Magri, Mario Clerici, Mara Biasin, Luca Piacentini, Silvia Della Bella, Adriano Boasso, Laboratory of Immunology, DSP LITA Vialba, Universita' degli Studi di Milano, Via G.B. Grassi 74, 20157 Milano, Italy; Paola Dall'Ara, Maria Laura Giannino, Piera Anna Martino, Claudia Pollera, Maria Puricelli, Francesco Servida, Wilma Ponti and Giorgio Poli, Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Microbiologia e Immunologia, Universita' degli Studi di Milano, Centro di Eccellenza sulle Malattie Neurodegenerative, Milan, Italy; Maria Caramelli, Cristina Casalone, Paola Gazzuola, Ines Crescio, Centro per lo Studio e le Ricerche sulle Encefalopatie Animali e Neuropatologie Comparate, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta, Torino, Italy; Renato Longhi, Istituto di Biocatalisi e Riconoscimento Molecolare, C.N.R., Milano, Italy; Silvia Della Bella, The Immunology Department of Biomedical Sciences and Technologies, University of Milan, Milan, Italy
SP englisch
PO Niederlande