NR ARXX
AU Williams,E.S.; Young,S.
TI Chronic wasting disease of captive mule deer: a spongiform encephalopathy.
QU Journal of Wildlife Diseases 1980 Jan; 16(1): 89-98
IA http://www.jwildlifedis.org/cgi/content/abstract/16/1/89
PT journal article
AB In the past 12 years (1967-79) a syndrome we identify as chronic wasting disease has been observed in 53 mule deer (Odocoileus hemionus hemionus) and one black-tailed deer (Odocoileus hemionus columbianus) held in captivity in several wildlife facilities in Colorado and more recently in Wyoming. Clinical signs were seen in adult deer and included behavioral alterations, progressive weight loss and death in 2 weeks to 8 months. Gross necropsy findings included emaciation and excess rumen fluid admixed with sand and gravel. Consistent histopathologic change was limited to the central nervous system and characterized by widespread spongiform transformation of the neuropil, single of multiple intracytoplasmic vacuoles in neuronal perikaryons and intense astrocytic hypertrophy and hyperplasia. Presented is a clinical characterization of chronic wasting disease and pathologic evidence supporting the conclusion that the disease is a specific spontaneously occurring form of spongiform encephalopathy.
IN Das Chronic Wasting Disease wurde zuerst 1967 in Colorado und 1978 in Wyoming bei Hirschen beobachtet, die in Forschungsstationen lebten. Bis 1979 wurde diese Prion-Krankheit bei 53 Maultierhirschen (Odocoileus hemionus hemionus) und einem Schwarzschwanzhirsch (Odocoileus hemionus columbianus) diagnostiziert, die alle in Gehegen lebten. Die Autoren halten aber offenbar eine spontane Entstehung für wahrscheinlicher als ein Überspringen von Scrapie auf Hirsche und eine anschließende Übertragung unter diesen.
MH Animals; Brain/pathology; Central Nervous System Diseases/pathology/*veterinary; *Deer; Female; Male; Research Support, U.S. Gov't, P.H.S.; Spinal Cord/pathology
SP englisch
PO USA