NR ASDS
AU O'Rourke,K.I.; Melco,R.P.; Mickelson,J.R.
TI Allelic frequencies of an ovine scrapie susceptibility gene
QU Animal Biotechnology 1996; 7(N2): 155-62
PT Article
AB The allelic frequencies of an ovine gene associated with susceptibility to scrapie was analyzed in a sample of 30 scrapie affected sheep and 545 clinically normal sheep from 12 flocks. The allele encoding glutamine at codon 171 occurred at a frequency of 0.76 in the overall population. All 30 scrapie affected sheep were homozygous for glutamine at codon 171. This genotype was observed in 56.5% of the clinically normal sheep. None of the 30 scrapie affected sheep carried the allele encoding Valine at codon 136 although this allele was observed in 2/12 flocks sampled.
IN Eine Analyse von 30 an Scrapie erkrankten und 545 gesunden Schafen aus 12 Herden ergab, dass alle 30 Scrapie-Schafe homozygot Glutamin an der Position 171 des Prionproteins aufwiesen. Diesen Genotyp besaßen auch 56,5% der gesunden Tiere. Keines der erkrankten Chafe besaß ein Valin an Position 136.
ZR 24
SP englisch