NR ASIT
AU Brown,S.A.; Merritt,K.; Woods,T.O.; Busick,D.N.
TI Effects on instruments of the World Health Organization - recommended protocols for decontamination after possible exposure to transmissible spongiform encephalopathy-contaminated tissue
QU Journal of Biomedical Materials Research. Part B, Applied Biomaterials 2005 Jan 15; 72(1): 186-90
PT journal article
AB It has been recommended by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) that rigorous decontamination protocols be used on surgical instruments that have been exposed to tissue possibly contaminated with Creutzfeldt-Jakob disease (CJD). This study was designed to examine the effects of these protocols on various types of surgical instruments. The most important conclusions are: (1) autoclaving in 1N NaOH will cause darkening of some instruments; (2) soaking in 1N NaOH at room temperature damages carbon steel but not stainless steel or titanium; (3) soaking in chlorine bleach will badly corrode gold-plated instruments and will damage some, but not all, stainless-steel instruments, especially welded and soldered joints. Damage became apparent after the first exposure and therefore long tests are not necessary to establish which instruments will be damaged.
MH Animals; Cattle; Corrosion; Decontamination/legislation & jurisprudence/*methods/*standards; Electrodes; Humans; Prion Diseases/*prevention & control/transmission; Sheep; Surgical Instruments/standards; *World Health Organization
AD United States Food & Drug Administration, Center of Devices and Radiological Health, Office of Science and Technology, Rockville, MD 20850, USA. sab@cdrh.fda.gov
SP englisch
PO USA