NR ASIX
AU Cordeiro,Y.; Silva,J.L.
TI The hypothesis of the catalytic action of nucleic acid on the conversion of prion protein
QU Protein and Peptide Letters 2005 Apr; 12(3): 251-5
PT journal article; review; review, tutorial
AB The main hypothesis for prion diseases proposes that the cellular protein (PrPc) can be altered into a misfolded, beta-sheet-rich isoform (PrPsc). We describe here that host nucleic acid may catalyze the conversion between PrPc and PrPsc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.
ZR 37
MH DNA/chemistry/metabolism; *Nucleic Acids/chemistry/metabolism; *PrPc Proteins/chemistry/metabolism; PrPsc Proteins/chemistry/metabolism; *Protein Conformation; Protein Folding; Recombinant Proteins/chemistry/metabolism; Research Support, Non-U.S. Gov't
AD Departamento de Bioquimica Medica, Centro Nacional de Ressonancia Magnetica Nuclear de Macromoleculas, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, RJ 21941-590, Brazil.
SP englisch
PO Niederlande