NR ASLW
AU Zou,W.Q.; Gambetti,P.
TI From microbes to prions the final proof of the prion hypothesis
QU Cell 2005 Apr 22; 121(2): 155-7
KZ Cell. 2005 Apr 22;121(2):195-206. PMID: 15851027
PT comment; journal article; review
AB Much like the "microbe hypothesis" put forth over 150 years ago, the "prion hypothesis" can be definitely proven only if a prion disease is engendered in a natural host from an infectious prion produced in vitro. In this issue of Cell, come very close to accomplishing this goal by producing a prion disease in a natural host from a prion entirely generated in vitro using a PCR-like amplification system.
ZR 10
MH Animals; Humans; PrPsc Proteins/*chemistry/*metabolism; Prion Diseases/*metabolism
AD Division of Neuropathology, Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
SP englisch
PO USA