NR ASTC
AU Bertram,L.; Tanzi,R.E.
TI The genetic epidemiology of neurodegenerative disease
QU Journal of Clinical Investigation 2005 Jun; 115(6): 1449-57
IA http://www.jci.org/cgi/content/full/115/6/1449
PT journal article; review; review, tutorial
AB Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous system. In fact, it has been the very knowledge gained from genetic studies that has allowed the elucidation of the molecular mechanisms underlying the etiology and pathogenesis of many neurodegenerative disorders. In this review, we discuss the current status of genetic epidemiology of the most common neurodegenerative diseases: Alzheimer disease, Parkinson disease, Lewy body dementia, frontotemporal dementia, amyotrophic lateral sclerosis, Huntington disease, and prion diseases, with a particular focus on similarities and differences among these syndromes.
ZR 99
MH Chromosome Mapping; *Epidemiology, Molecular; Genetic Predisposition to Disease/*genetics; Nerve Degeneration/epidemiology/*genetics/pathology; Neurodegenerative Diseases/*epidemiology/*genetics/pathology; *Physical Chromosome Mapping; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
AD Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. bertram@helix.mgh.harvard.edu
SP englisch
PO USA