NR ASTT
AU Kryndushkin,D.S.; Aleksandrov,I.M.; Kushnirov,V.V.; Ter-Avanesian,M.D.
TI [Yeast as a model for studying the prion and amyloid occurrence]
OT Drozhzhi kak model' dlia izucheniia molekuliarnykh osnov vozniknoveniia prionov i amiloidov
QU Rossiiskii Fiziologicheskii Zhurnal Imenti I.M. Sechenova / Rossiiskaia Akademiia Nauk 2004 May; 90(5): 645-57
PT journal article; review; review, tutorial
AB Recent data on the use of yeast as a model for studying the molecular basis of prion infection are summarized. In contrast to mammalian prions, which are related to incurable neurodegenerative diseases, yeast prions determine the appearance of non-chromosomally inherited phenotypic traits. Prions of yeast are structurally similar to amyloids of mammals and their replication involves not only growth, but also fragmentation of prion amyloid-like fibrils. In mammals the fragmentation should lead to an increase in infectious titer. The use of yeast for study of the mechanisms of human amyloidoses, development of new anti-prion drugs and search for new proteins with prion properties is described.
ZR 62
MH Amyloid/genetics/*metabolism; Animals; English Abstract; Humans; Molecular Chaperones/genetics/metabolism; Prion Diseases/*metabolism/pathology; Prions/genetics/*metabolism; Saccharomyces cerevisiae/genetics/*metabolism; Saccharomyces cerevisiae Proteins/genetics/*metabolism
SP russisch
PO Russland