NR ASUR
AU Cepek,L.; Steinacker,P.; Mollenhauer,B.; Wiese,B.; Ciesielczyk,B.; Bibl,M.; Wiltfang,J.; Zerr,I.; Schulz-Schaeffer,W.J.; Kretzschmar,H.A.; Poser,S.; Otto,M.
TI Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
QU Dementia and Geriatric Cognitive Disorders 2005; 19(5-6): 376-82
PT journal article
AB BACKGROUND: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. PATIENTS AND METHODS: We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. RESULTS: Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. CONCLUSION: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases.
MH Adult; Aged; Aged, 80 and over; Alzheimer Disease/cerebrospinal fluid/diagnosis; Biological Markers/cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis; Dementia/cerebrospinal fluid/diagnosis; Diagnosis, Differential; Encephalitis/cerebrospinal fluid/diagnosis; Epilepsy/cerebrospinal fluid/diagnosis; Female; Follow-Up Studies; Hepatic Encephalopathy/cerebrospinal fluid/diagnosis; Humans; Male; Middle Aged; Neoplasms/cerebrospinal fluid/diagnosis; Nerve Growth Factors/*cerebrospinal fluid; Neurodegenerative Diseases/cerebrospinal fluid/diagnosis; Research Support, Non-U.S. Gov't; S100 Proteins/*cerebrospinal fluid; Uremia/cerebrospinal fluid/diagnosis; tau Proteins/*cerebrospinal fluid
AD Department of Neurology, University of Göttingen, Göttingen, Germany.
SP englisch
PO Schweiz