NR ASUY
AU Ivanyi-Nagy,R.; Davidovic,L.; Khandjian,E.W.; Darlix,J.L.
TI Disordered RNA chaperone proteins: from functions to disease.
QU Cellular and Molecular Life Science 2005 Jul; 62(13): 1409-17
PT journal article
AB RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
MH Animals; Capsid Proteins/metabolism; Fragile X Syndrome/metabolism; Gene Products, gag/metabolism; HIV Infections/metabolism; HIV-1; Humans; Mental Retardation/metabolism; Molecular Chaperones/*metabolism; Nerve Tissue Proteins/metabolism; Prion Diseases/metabolism; Prions/metabolism; Protein Conformation; RNA/*metabolism; RNA-Binding Proteins/metabolism; Research Support, Non-U.S. Gov't; Structure-Activity Relationship; Viral Proteins/metabolism
AD Unite de Virologie Humaine (412), Ecole Normale Superieure de Lyon et Institut National de la Sante et de la Recherche Medicale, IFR 128, 46 allee d'Italie, 69 364 Lyon, France.
SP englisch
PO Schweiz