NR ASWK
AU Campbell,P.N.
TI Bovine spongiform encephalopathy - some surprises for biochemists
QU IUBMB Life 2005 Apr-May; 57(4-5): 273-6
PT journal article; review; review, tutorial
AB Bovine Spongiform Encephalopathy (BSE) is typical of the dementias that affect both animals and man; Scrapie in sheep, Creutzfeldt-Jakob disease in man. Global efforts have been made to determine the nature of the active agents in these diseases. At present the 'protein only hypothesis' of Prusiner holds. It was a surprise that a protein could per se be the active agent but other surprises for our traditional teaching of biochemistry arose. These are explained in a brief summary of our present understanding of the biochemistry of the active agents that cause the diseases.
ZR 16
MH Animals; Cattle; Creutzfeldt-Jakob Syndrome/metabolism; Encephalopathy, Bovine Spongiform/*diagnosis/*metabolism; Humans; Models, Biological; Prions/chemistry; Protein Conformation; Protein Structure, Tertiary; Scrapie/metabolism
AD Department of Biochemistry and Molecular Biology, University College London, London, UK
SP englisch
PO England