NR ASZU
AU Head,M.W.; Peden,A.H.; Yull,H.M.; Ritchie,D.L.; Bonshek,R.E.; Tullo,A.B.; Ironside,J.W.
TI Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease
QU The British Journal of Ophthalmology 2005 Sep; 89(9): 1131-3
PT journal article
AB BACKGROUND: Involvement of the eye has been reported in patients with variant Creutzfeldt-Jakob disease (vCJD), but there is disagreement on whether retinal involvement occurs in sporadic Creutzfeldt-Jakob disease (sCJD). METHODS: Western blotting, paraffin embedded tissue blotting, and immunohistochemistry were used to test whether the abnormal form of the prion protein (PrPsc) accumulates to detectable levels in the eye in a case of the most common subtype of sCJD (MM1). RESULTS: Low levels of PrPsc were detectable in the retina, localised to the plexiform layers of the central retina. PrPsc was not detectable in other ocular tissues. CONCLUSIONS: The abnormal form of the prion protein is present in the retina in the most common sCJD subtype (MM1), albeit at levels lower than those found previously in vCJD and in sCJD of the VV2 subtype.
IN Auch beim häufigsten Typ (MM1) sporadischer Creutzfeldt-Jakob-Krankheit wurde PrPsc in allerdings geringer Konzentration in der Retina gefunden.
MH Aged; Blotting, Western/methods; Creutzfeldt-Jakob Syndrome/*metabolism; Humans; Immunohistochemistry; Male; Paraffin Embedding; PrPsc Proteins/*analysis; Research Support, Non-U.S. Gov't; Retina/*chemistry
AD National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, University of Edinburgh EH4 2XU, UK. m.w.head@ed.ac.uk
SP englisch
PO England