NR ATDP
AU Marsh,R.F.; Kincaid,A.E.; Bessen,R.A.; Bartz,J.C.
TI Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)
QU Journal of Virology 2005 Nov; 79(21): 13794-6
IA http://www.cwd.cc/Interspecies_Transmission_of_Chronic_Wasting_Disease.pdf
PT journal article
AB Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrPres, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
IN Zwei adulten weiblichen Totenkopfaffen wurden je 200 µl eines Homogenates mit 20% (M/V) Gehirn einer am CWD erkrankten Hirschkuh intrazerebral inokuliert. Beide erkrankten und mussten daher 31 bzw. 34 Monate nach der Inokulation getötet werden. In den Gehirnen beider Affen fand man PrPsc und spongiforme Veränderungen.
MH Animals; Brain/metabolism/pathology; *Disease Transmission, Horizontal; Monkey Diseases/pathology/*transmission; PrPsc Proteins/metabolism; Saimiri; Species Specificity; Wasting Disease, Chronic/pathology/*transmission
AD Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
SP englisch
PO USA