NR ATES
AU Ward,H.J.T.; Everington,D.; Cousens,S.N.; Smith-Bathgate,B.; Leitch,M.; Cooper,S.A.; Heath,C.; Knight,R.S.G.; Smith,P.G.; Will,R.G.
TI Risk factors for variant Creutzfeldt-Jakob disease: a case-control study.
QU Annals of Neurology 2006 Jan; 59(1): 111-20
PT journal article
AB OBJECTIVE: To investigate the potential risk factors for variant Creutzfeldt-Jakob disease (VCJD) in the United Kingdom. METHODS: Definite and probable vCJD cases (n = 136) were residing in Great Britain at disease onset, and were referred between May 1995 and November 2003. Control subjects (n = 922) were recruited between 2002 and 2003, from 100 randomly selected geographical clusters sampled to represent the geographical distribution of vCJD. RESULTS: Reported frequent consumption of beef and beef products thought likely to contain mechanically recovered or head meat, or both, including burgers and meat pies, was associated with increased risk for vCJD, as was reported frequent chicken consumption. Surgical operations were generally similarly reported for cases and control subjects, with the exception of a small group of minor operations, possibly attributable to underreporting in control subjects. Cases and control subjects had similar reported occupational histories and exposure to animals. INTERPRETATION: These findings are consistent with dietary exposure to contaminated beef products being the main route of infection of vCJD, but recall bias cannot be excluded. There was no convincing evidence of increased risk through medical, surgical, or occupational exposure or exposure to animals.
IN Eine britische Fall-Kontroll-Studie mit 136 nvCJK-Fällen und 922 Kontrollpersonen bestätigte den statistischen Zusammenhang zwischen nvCJK und häufigem Konsum von Fleischprodukten wie Hamburgern und Fleischpasteten, die oft maschinell von Knochen abgelöstes Fleisch oder Kopffleisch enthielten. Ein Zusammanhang zwischen nvCJK und Operationen oder Tierkontakten war nicht erkennbar.
MH Adolescent; Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cattle; Child; Creutzfeldt-Jakob Syndrome/epidemiology/*etiology; Diet; Female; Great Britain/epidemiology; Humans; Male; Middle Aged; Questionnaires; Random Allocation; Research Support, Non-U.S. Gov't; Retrospective Studies; Risk Factors
AD Hester J. T. Ward (h.ward@ed.ac.uk), Dawn Everington, Blaire Smith-Bathgate, Margaret Leitch, Sarah Cooper, Craig Heath, Richard S. G. Knight, Robert G. Will, National Creutzfeldt-Jakob Disease Surveillance Unit, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; Simon N. Cousens, Peter G. Smith, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
SP englisch
PO USA