NR ATJP
AU Konold,T.; Sayers,A.R.
TI Assessment of Heart Rate Variability Analysis as a Differential Diagnostic Tool in Bovine Spongiform Encephalopathy (BSE)
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Diagnosis DIA-01
PT Konferenz-Poster
AB
Transmissible spongiform encephalopathies in ruminants are diseases of the brainstem characterised by neuronal vacuolation and accumulation of proteinase-resistant prion protein (PrPres) particularly, and most consistently, in the dorsal motor nucleus of the vagal nerve (DMN). Abnormalities of heart rate variability (HRV) have been detected in diseases affecting the brainstem in humans, and measurement of HRV has been used to assess sympathetic and parasympathetic autonomic effects on the heart. In naturally infected BSE cases an increased parasympathetic tone resulting in bradycardia has been observed, and perturbation of HRV has been detected during the incubation period in experimental disease in cattle.
This study tested the hypothesis that BSE in cattle results in abnormalities of HRV that allows differentiation from healthy cattle and cattle reported as BSE suspects without pathological confirmation and without changes in the DMV.
Electrocardiograms (ECGs) of 5 min were recorded from 13 adult cows affected by natural BSE, 18 BSE suspect cows that were not confirmed as BSE cases by postmortem tests and 6 clinically healthy cows with a negative postmortem diagnosis of BSE. Heart rate, low frequency power (LF, 0-0.16 Hz), high frequency power (HF, 0.16-0.7 Hz) and the LF/HF ratio were calculated by Fourier transform on tachygrams of instantaneous frequency (frequency domain analysis). Statistically significant differences were not found in any of the parameters measured among the three groups (p>0.05, ANOVA on log-transformed values). We conclude that frequency domain analysis of ECGs of 5 min duration was not useful to distinguish BSE cases from unconfirmed BSE suspects or healthy cattle.
AD T.Konold, A.R.Sayers, Veterinary Laboratories Agency Weybridge, UK
SP englisch
PO Deutschland