NR ATJY
AU Yun,S.W.; Gerlach,M.; Riederer,P.; Klein,M.A.
TI Oxidative stress is an early event in scrapie pathogenesis
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Diagnosis DIA-10
PT Konferenz-Poster
AB Oxidative stress has been shown to be involved in the pathogenesis of prion disease, or transmissible spongiform encephalopathy. Although a growing body of evidence suggests direct involvement of oxidative stress in the pathogenesis of prion diseases, it is still not clear whether oxidative stress is a causative early event in these conditions or a secondary phenomenon commonly found in the progress of neurodegenerative diseases. We found significantly increased concentration of lipid peroxidation markers, malondialdehyde and 4-hydroxyalkenals, and mRNA level of an oxidative stress response enzyme, heme oxygenase-1, which precede a dramatic decrease in synaptophysin expression in the brain of scrapie-infected mouse. Furthermore, increased lipid peroxidation in the brain was detectable even before the accumulation of pathological form of the prion protein, PrPsc. These findings suggest that oxidative stress casually contributes to murine scrapie pathogenesis, predisposing the brain to neurodegerative mechanisms that characterize prion diseases.
AD Seong-Wook Yun, Manfred Gerlach, Peter Riederer, Michael A. Klein, University of Würzburg, Germany
SP englisch
PO Deutschland